Zinc Metallothionein,Zn-MT,Zn MT,MT-1,MT-2,MT-3

As manufacturer and supplier,we can supply:

1 Zinc metallothionein extracted from rabbit liver
   Zn-MT  70%,90%,95%
   Zn-MT-I   95%,99%
   Zn-MT-II  95%,99%

2 Recombiant human zinc metallothionein,expressed in E.coli.
   Zn-MT-III  95%,98%,99%

Appearance:  White freeze-dried powder.
The main types of metal:  Zinc
Molecular Weight: 6500kDa
Storage:  4ºC  1 year;-20ºC 1-3 years;-70ºC  3-5 years.

3 Rabbit liver Metallothionein I  anti-Serum (mouse)
   Rabbit liver Metallothionein I purified antibody (mouse,monoclonal)  95%
   Human Metallothionein III Anti-serum (rabbit)
   Human Metallothionein III puified antibody (rabbit,monoclonal)  95%

Purity is determined by SDS-PAGE and HPLC.

Applications of MT

MT and Senility
  In the vital processes of organisms, once they have grown into being mature, their morphological structure and physiological functions have some chronic, progressive and retrogressive changes as aging. These changes bring harmful effects to the organisms; their adaptability and reserve capability weaken constantly. This change remains non-stop and developing, we call it senility. Cell senescence is the base of human body senility. Those stricken cells have a series of relative changes, such as cell turbidity, bulge, cell receptor weakening, oxidizing enzyme activity reducing, etc. Furthermore, there will be a kind of lipofuscin deposited in the cells, which is one of the characteristics of senility.  
  During metabolism, the breathing cells produce free radicals constantly, which are harmful to the cells, so the main reason of senility is actually the constant free radical reactions in the cells and tissues. This is a decisive factor to life times. So anti-oxidant, also called free radical scavenger, is the determinative factor to mammals’ life times.
  There is an anti-oxidation system in our body and MR is one of its members. It possesses a remarkably ability to scavenge the free radicals. When people become middle aged, it is considerable to supplement MT since it is helpful to postpone senility, prevent diseases, improve the life quality of the elders and allow them to keep young and healthy.

MT and Beautification
  As the age increases, both organs and functional structure of cells degenerate. This is called aging.Its obvious sign is the skin decaying, and the typical symptom is the appearance of the senile plague, namely, the brownish - black plague of spot on the olds' faces and hands.In addition, some environmental factors (e.g. sunlight, ultraviolet radiation, etc.) may also bring some changes as freckle, pruritus, dryness, roughness or dermatitis on the skin tissue. All these changes not only affect beauty but also prevent the skin tissue from exerting its functions.Therefore, the skin-nursing has attracted wide attention. Research on mechanism of the skin decay and its protective measures have also become an important task of medial experts and beauty-specialists.
  As a protective covering of the organism, the skin tissue acts as the important physiological barrier to resist outside invasion and ensure healthy physique. The skin tissue is even more vulnerable to nocuous stimulation because of its role of the human body covering.It consists of many cells and intercellular substances with various functions. And its structural function is exactly the basis on which the skin is ensured of fineness, smoothness, softness and moisture.In normal cases, the sebum excreted by the skin tissue keeps the skin moisturized.The sebum is mainly composed of unsaturated fatty acid, saturated fatty acid and glycerine. They, together with the water content and other substances excreted by the sweat gland and epidermal cell, form a layer of butterfat plasmolemma to prevent the skin from dryness and rhagades. Ageing and some outside factors (e.g. the sunlight) make the organism and skin
tissue produce too many free radicals to allow the organism scavenge them. So the skin tissue is harmed by the free radicals just like other tissues are, and thus the unsaturated fatty acid and some proteins come into being under the effect of free radicals and tyrosinase.In addition, two other substances are detected in the senile or denatured skin tissues: lipofuscin and ceroid, which cause the skin black and coarse. Free radical plays a key role in forming such two types of adhesive substances.Under the effect of free radicals and dioxygenase, lipid changes its form into lipid peroxide, the latter polymerizes and cross-links with some proteins and phospholipids to form into the lipofuscin and ceroid.Another symptom of the skin decay is skin elasticity decreasing. There is a collagen contained in the skin intercellular substance which ensures soft skin.But, under the effect of free radicals, covalence glued connection appears among the collagens and form multi-polypeptide chains, thus decreases the solubility of collagen proteins.These multi-polypeptide chains prevent the nutriment from being distributed and therefore restrict the skin cell’s nutrition supply. This then causes the energy of skin tissue decrease, wrinkles appear and the skin loses elasticity.The sunshine helps promote the metabolism of skin and vitamin D and melanotropin to come into being, but a great deal of ultraviolet radiation may cause phototoxic reaction and allergic reaction upon skin, increase the free radical content. This explains why sunburn or windburn has obvious catalysis on the skin decay.
 In a word, if there are too much poisonous substances such as free radicals, heavy metals, endotoxin inside the body, the skin tissue will be changed and the skin decay will be accelerated.   
  Scientific experiments have discovered that MT is rich of sulfur radicals, which resists X-ray and ultraviolet radiation and scavenge or resist harms from free radicals, heavy metals, endotoxin and other poisonous substances.In fact, MT is by far the most effective protein for scavenging free radicals, and its capacity of scavenging free radicals, heavy metal and endotoxin is much greater than that of the familiar substances like superoxide dismutas (SOD), glutathione etc.Due to its high capacity of scavenging free radicals, heavy metal and endotoxin, MT attracts more and more attention. People have realized the important role MT plays in the process of life. As the people grow older, the organism’s ability to scavenge free radicals, heavy metal and endotoxin becomes weaker, meanwhile, the content of the inherent integrated antidote in their body decreases, so their skin and other tissues of their oganisms show signs of aging.So, proper replenishment of MT for the human body can prolong and prevent the aging of human skin and body, keeping skin soft and moisturized.In particular, the industry develops so rapidly nowadays that air pollution is destroying ozonosphere, inevitably leaving people vulnerable to more exposure to X-ray.  In addition, there are some chemical substances harmful to the skin in the air, so proper replenishment of MT for the body is all the more necessary.Proper replenishment of MT for the human body can prevent the skin and other organic parts from harms caused by free radicals, heavy metal, endotoxin and other poisonous substances, and ensure the normal function and energy for the skin and other tissues.

MT has six special functions with regard to beautification and skin care:  
  1 MT scavenges free radicals and hydroxide radicals, which cause aging, to postpone senility. The accumulation of free radicals in the organism is the major cause of senility. There are two main free radicals in the human body: hydroxide radical (·OH) and superoxide radical (·O3) which is transformed from (·OH). MT can effectively scavenge these two free radicals, especially (·OH). Moreover, with the nucleophilicity, its ability to scavenge free radicals is 10,000 times greater than that of SOD. Due to its homeology, MT does not cause any allergic reaction.
  2 Anti-radiation Function: The stress reaction of our body, caused by the exposure of our body and skin in the sunlight and beta ray, produce a great deal of active groups, including aging-seducing substances such as (•OH) and (•O3). The accumulation of these substances in our body and skin is harmful, but fortunately MT features in its salient anti-radiation function, reducing and avoiding the harms caused to the skin by radiation exposure and speeding up repairing and restoring the injured skin.So MT helps to resist radiation, repair solar dermatitis, quickly relieve the skin sensitivity caused by sunlight exposure, meanwhile, it also removes the pigment stains caused by sunlight exposure. Scientific experiments have proved that MT resists X-ray, ionize radiation and environmental pollutions (waste gas, waste water and soot); It effectively relieves the skin injuries caused by radiation, and it is especially conductive to the skin care of those who usually work outdoors or in front of fluorescent screen.
  3 Remove stains and avoid pigmentation: MT possesses an outstanding beautification function of scavenging free radicals, resisting aging, removing stains and decreasing wrinkles.
  4 Speeding up healing of the dermatitis: MT coordinates with cell growth factors, which promote the growth of epithelium cells; however, long-term use of cosmetics containing cell growth factors tends to cause dermatitis, even skin cancer. MT can avoid the poisonous side effects of the cosmetics.
   5 Relieve the Poisonous Effects of Heavy Metal: High content of (-SH) in MT cysteine determines that MT is able to scavenge Hg, Pb, and some other poisonous heavy metals. Each MT molecule can combine with 4 to 7 heavy metal atoms and its capacity of combining with heavy metal ions is 1,000 times greater than with ordinary metal ions. Once MT combines with heavy metal atoms, it will be easily transferred out of the body through the transportation function of our body.Due to the severe urban air pollution nowadays,the excessive heavy metal ions emitted from motor vehicles in the environment will cause poisoning symptoms. MT is rich of cysteine, and the cysteine- sulfhydryl group can combine with heavy metal ions such as Zn, Co, Pb, Cd, Silver, Hg, Bi etc. The combination process is reversible and quick. When the content of a certain metal ion in the body is excessive, MT will combine with them to keep the content positive; when the content is insufficient, MT releases the metal ions. As a physiological regulator, MT keeps the skin healthy and natural.
  6 Relieve Skin’s Allergic Reactions. Not being an irritant, MT does not cause allergic reactions.

MT & Children Zinc Deficiency
  Zinc (Zn) is an indispensable trace element for human body with extremely important physiological functions. The result for severe Zinc deficiency is unimaginable.Zinc(Zn) deficiency is decided by checking Zinc concentration in the blood. Normal content of Zinc concentration for children is 13.95±1.81 μmol/L.If zinc deficiency is confirmed, it can be treated depending on degree of deficiency. Traditional methods for Zinc supplementation are to treat patients with 1% Zinc Sulfate Solution, or Zinc Gluconate. There are side effects for both treatments, such as nausea or vomiting. They are not suitable for long-term use.
  With the constant development and progress of biological Hi-Tech, research on human Zinc supplementation has been arrived at molecular level at present time. Numerous animal experiments and clinics have proven that Zinc supplementation by Metallothionein (MT) can completely replace traditional Zinc supplementation methods. From the view of science, Metallothionein should be called Zinc Metallothionein (Zn-MT). In the molecular structure of Zn-MT, each Zn-MT molecule binds with 5-7 Zinc ions. After Zn-MT gets into human body, Zn ions are permuted soon, followed by a series of physiological reactions. Zinc ions then go into human cells and tissues and end the Zinc supplementation procedure.
  Zn-MT is a pure biological product extracted from animal body and then purified through Hi-Tech means,so it can also be called Biological Zinc. Biological Zinc can be taken orally or through intravenous injection. It’s easy to be absorbed by human body. The effect of using Zn-MT to supplement Zinc is either fast or efficient. Zn-MT has overcome disadvantages of traditional Zinc supplementation methods. It has no side effects, and can be taken for a long time.
  For children suffering Zinc deficiency, Zinc supplementation is of essential importance all life long. In time Zinc supplementation in a proper way can help human body grow healthily. It prevents all organs, especially their reproduction organs from being injured, fastens wound heal. Their taste buds will grow more sensitive and the children will have no anorexia, not picky in foods, stronger, smarter and more active. It can also improve immunity.keep the children away from diseases.Experiments have proven that after half an hour since the supplementation of Zinc Metallothionein, Zinc concentration in the human body will distinctly increase, arrive at its top value in an hour, and keep at high level for more than 8 hours.So Zinc supplementation can fill our life with wisdom, vigor and passion.For the importance of Zinc in our life, it is praised as “the Light of Life” in medicine.

MT and Tumor
  As a kind of commonly encountered and frequently-occurring disease, tumor endangers human health and life safety seriously. For many years, many researchers for basic medicine and clinical medicine have been doing much research effort widely and deeply on its cause of formation, laws of growth, clinic manifestation, also on its proper and efficiently diagnosis therapeutic programs. Free radical is lively intermediated in chemical, enzymatic and biologic reaction and abounds during the process of biologic macromolecule and organism damage. Generally, people have attached importance to free radical in its relations with tumor occurrence, growth and diagnose treatment. It has become an important research subject domain of free radical medicine and biology. Experiments have proved that many carcinogen produce carcinogenic effect through producing free radical directly or indirectly. This is one of the important factors cause and promote tumor.Overfull free radical in body can change cell structure and function by acting with many important intracellular biomolecule, such as nucleic acid, protein, lipid and carbohydrate, etc. so as to cause and promote the tumor to produce and develop. Free radical causing and promoting cancer is a multi-link and complex process. At the beginning phase of cancerization, free radical and other carcinogens act with DNA, then result in chromosome damage and gene mutation. During the process of promoting cancer, free radical not only show gene expression in causing mutation by damaging DNA, but also bring phenotypic expression in damaging other biomolecule such as protein, lipid, etc. As mentioned above, free radical makes tumor to appear and develop through various and multi-level action.    
  Study shows, as a free radical scavenger, MT can scavenge the garbage within body­--free radical, reduce the damage to organism caused by free radical, stimulate organism immunologic function, build up organism functions of cancer prevention and anticancer. Furthermore, MT can reduce the side effect of radiotherapy and chemotherapy, for example, S+ contained in MT can combine with cisplatin easily, which means it may reduce the toxicity of cisplatin to part organism tissue and organs. Meanwhile, MT can increase the sensitivity of tumor to cisplatin.Therefore, MT helps tumor patients as an assistant treatment.

MT & Coronary Heart Disease
  Coronary atherosclerotic cardiopathy is a type of heart disease caused by atherosclerosis of coronary artery. Its abbreviation is coronary heart disease.In the United States, 700,000 people are dying of this disease every year, which accounts for 1/3 of the total number of deaths. The morbidity rate of coronary heart disease has something to do with population aging. The cases were also found in the middle-aged people who contribute most to the society and who are supposed to be the most energetic group. Coronary heart disease is the main reason that accounts for the sudden deaths of the elders. The principal clinical manifestations of coronary heart disease are angina pectoris, myocardial infarction and sudden death.  The research findings tell us that, at the molecular level, the development of atherosclerosis is connected with free radical, namely, metabolic wastes of human body. Free radical is also called aging determinative factor or pathogenic meditative factor.It is revealed in the findings that patients suffered from atherosclerosis have an increase of lipid peroxidation in the blood plasma, which is in positive correlation with cholesterol and triglyceride.All these prove that certain pathologic process of atherosclerosis is related with the damage of lipid peroxidation; however, lipid peroxidation is triggered off by free radical.On one side, free radical and lipid peroxidation can lead to swelling and damage of endothelial cell in the blood vessel, thus lead to arterial sclerosis.On the other side, with the influence of free radical, low-density lipoprotein forms low-density lipoprotein that is substantially deposited in the endothelial cell and eventually forms atherosclerosis.Besides, low-density lipoprotein peroxide can suck platelet aggregation and impel large production of free radical, thus, it accelerates the development of atherosclerosis.
  It has been measured that the oxidation resistance degrades in the patients suffered from atherosclerosis. So the free radical can not be scavenged from the body in time, therefore, it causes the pathologic changes of organism. Up to now, MT is the most powerful protein that can scavenge free radicals. It is 10,000 times stronger than SOD. Supplementing exogenetic MT is effective to prevent and cure coronary heart disease. In Japan, MT has obtained patent and has been applied to clinics as a method for curing myocardial infarction.

MT & Diabetes
  Diabetes, a disease among the elders, is very harmful to the human body and causes great inconvenience to the patients' lives.The cause of the disease lies in the following fact: the absolute or relative lack of insulin secreted by the pancreas causes metabolic disorder of sugar, fat, protein, water and electrolytes, and then the blood sugar rises while the test of urine sugar becomes positive.The clinic symptoms are described as "Three More and One Less", i.e., the patients will drink and eat more, produce more urine while lose weight.The usual complications of diabetes include high blood pressure, cardiovascular diseases like arteriosclerosis and kidney diseases, so the prevention and treatment of diabetes comes to people’s attention.
  Its pathogenesis shall be firstly understood to prevent diabetes.There are many factors caused the diabetes, for example, hypertension, obesity, smoking and the like.At present, new study data present that it is relating with the damage of pancreas’ B cells caused by free radicals. Under the normal conditions, the pancreas’ B cells are the basic unit producing and excreting the insulin, which includes the system to scavenge the free radicals. Therefore, the free radicals cannot cause damage to the pancreas’ B cells. However, the B cells will be damaged under the impact of chemical or immune factors, which ability against the free radicals will reduce correspondingly, causing the gathering of free radicals. It will apparently destroy the structure of B cells, influencing the excretion of the insulin, and finally produce the diabetes. Experiments show that the content of free radicals in serums of patients suffered from type-I diabetes (insulin dependent diabetes mellitus) and type-II diabetes (non-insulin dependent diabetes mellitus) obviously increases while the content of antioxidants obviously decreases.The content of free radicals in blood vessels of patients suffered from diabetes complicated with vascular pathologic changes increases even more overtly and its scavenging ability for free radicals obviously reduces too. So, the free radical damage is the important factor to produce diabetes and its syndrome.The free radicals not only damage the structure of B cells and affect the excretion of insulin, but also produce the arteriole’s fibering pathologic change, arteriosclerosis and angiocardical diseases under the influence of the peroxide products of unsaturated fatty acid, which caused by free radicals, restrict biologic synthesis of the prostacyclin, and make anticoagulin lose activeness and the blood flow to be at a highly coagulated state. And therefore it is easy to induce the thrombosis, impede the microcirculation and appear macrovasculopathy & microcirculation pathologic changes.As a result, scavenging the free radicals is an important way to prevent and treat diabetes & its syndromes.So far, it has been found that MT is the most powerful non-apoenzyme to scavenge the free radicals in human body. Because it includes many metal atoms and 20 reductive SHs, it can effectively prevent and treat the diabetes & its syndromes.

MT & Cataract
  Cataract, one of the common eye diseases of the aged, has a rather high incidence which rises while ageing.It was reported that the inclination of old people suffering cataract is related to the decrease of the organism’s resistant capacity to free radicals, namely, the harm of free radicals is closely related to the occurrence of various cataracts.   Researches showed that the content of free radicals in the senile cataract patents’ eye-fluid (including eye-water and glassy body fluid) is 2 or 3 times more than it of the normal people.Examinations showed that the peroixide products of free radicals in the cataract patents’ eye fluid are obviously excessive, especially to the patents with brown cataract than with yellow cataract. It demonstrates that free radicals or their peroixide products play important roles in the process of forming cataract.  
  Normally the production and being scavenged of free radicals are in a dynamic balance since there is the scavenging system while the free radicals are produced constantly in our eyes.But along with ageing, the eye’s capacity of scavenging free radicals decreases. Hence the surplus of free radicals in the eye ( including II 202,oxygen free radicals, hydroxyl free radicals , etc .) which can not only oxidize the important –SH radicals in protein,enzyme and membrane albumen in the eye so as to make the proteins cross-link themselves and the activeness of proteinase lose, but also be an meaningful factor to arouse cataract because of the peroixidizing of the crystalline lens lipid by free radicals.Various free radicals produced in the course of peroixidizing fats also peroixidizes the amino acids in proteins and destroy the structures of proteins.When fatty peroixide interract with protein and phophatide , and the blended albumen comes to undissolved high-molecular compound , the transparency of crystalline lens are gradually reduced.The injured crystal albumen can neither be removed in the way of decomposing , nor be replaced by new protein because of  the disability of synthetizing albumen from crystalline lens and the low capacity of metabolizing of crystalline lens . Thus result in cataract.
  It’s proved by experiments that the forming process of cataract can be prevented by free radical eradicator , while the latter can reduce the turbidity of crystalline lens.MT is the great free radical eradicator that can eradicate the excessive free radical in the body (including in the eye ) . Protect crystalline lens from free radical so as to prevent cataract . Taking in additional MT beside daily diet can not only guar against the development of cataract , but also is good for cataract treatment , especially for those aged with cataract.

MT & Radiation
  The deadly harmful radiation results in pathological changes to mankind productive system, hemopoietic system, nervous system, digestive system and so on. For example, the quantity and quality of male sperm decreases, the female ovulation declines, anemia, or to the worst ----leukemia, nausea and vomit appear. Injury by ionization radiation begins from the period of physical change when the body absorbs the radiant energy, then periods of physical and biological changes until the tissue cells are injured or the organisms go dead.   
  Radiation producing free radicals and other bioactive substances damage the important macromolecules in human body is regarded as the major reason of injury. The phenomina occurred in the development of radiation injury, the biological injury , the change of tissue pattern and the syndrome of radiation diseases, can all be regarded as a series of successive or indirect effects of the damages caused by free radicals.Under ionization radiation, moisture in the body is excited to the excited state or ionized to a positive molecule and an electron, and then decomposed to highly active free radicals . Though with the free radical scavenging system in the body , when free radicals in the body come to surplus  because of radiation, those excessive free radicals will attack or destroy biological macromolecules, such as protein, unsaturated fatty acids, DNA or the structure of some enzymes, causing premature senility, shorter life-span, tumor or other blood diseases, or even going so far as to affect man’s gene.To be concluded, it’s a critical measure to avoid radiation injury by preventing radiation from arousing the production of harmful free radicals.Experiments have proved that the cells and tissues containing rich MT can effectively help to resist tissue injury by ionization radiation or ultraviolet ray.In fact, MT can strongly scavenge excessive free radicals in the body, protect the body from injury. As a result, people getting in touch frequently with radiation can prevent diseases caused by radiation in the way of taking in appropriate supplementation of MT.For those sufferers from cancer, the supplementation of MT can enhance the effect of radiotherapy and chemotherapy, meanwhile prevent or reduce the harmful effects to the body from radiation.

MT & Alimentary Canal Ulcer
  Alimentary canal ulcer is a disease mainly due to the damages to the mucous membrance of the stomach or of the duodenal. The clinical symptons are empty stomachache or upset stomach, hiccup, acid regurgitation, salivation, etc.There may be various reasons with alimentary canal, such as hyperchlorhydria , drinking , smoking , nervousness ,  diet inbalance or bad effect of medicine etc. It’s discovered by Soldats and some other experts in 1985 that free radicals play an important role in the occurrence of acute or chronic gastritis, alimentary canal ulcer and gastric carcinoma. It has been examined that the contents of free radicals increase obviously in the serum of the sufferers from such diseases as alimentary canal ulcer, acute or chronic gastric carcinoma. To the contrast, the capacity of scavenging free radicals decreases.
  Gastric mucous membrane and duodenal mucous membrane have a strong capacity to produce free radicals.Under normal conditions, the defensive system can scavenge free radicals and maintain the content of free radicals to the extent that does not injure the tissues.However, the capacity of scavenging free radicals is limited.Under chemical materials or under stress conditions (hunger, nervousness, etc.) , the exciting of sympathetic-adrenal gland causes the systole of alimentary canal vessels, leaving the mucous membrane in a state of blood deficiency. This then leads to plentiful free radicals by means of NADPH oxygen-reduction cycle and the catalysis of xanthenes-oxidizing enzyme in the course of recovery of blood-deficiency.Furthermore, ulcer sufferers often suffer complicating diseases as gastritis and duodenitis, which leads to the fathering of a great amount of leucocyte through the outbreak of leucocyte breathing to produce a huge amount of free radicals to kill bacteria.Too many free radicals surpass organisms’ capacity to scavenge them, and they come to surplus in the alimentary canal mucous membrane. The excessive free radicals cause the peroxidizating of fats in the cell membrane of mucous membrane, destroy the structure and function of cells, destruct the shelter of alimentary canal mucous membrane, in the end, lead to ulcer.
  Through the pathogenesis of ulcer, we may find that free radicals play an important role in the process of development of an ulcer. If the excessive free radicals are scavenged before or during the process, the ulcer will be able to be prevented. MT is a powerful free radical scavenger with a low molecular weight; it is easy to be absorbed. It can scavenge the excessive free radicals in the alimentary canal, so as to prevent the mucous membrane cell from being injured and thus prevent ulcer.

MT & Liver Diseases
  Liver diseases, such as hepatitis, cirrhosis, fatty liver , liver cancer, which have a high incidence , are deadly harmful to man and have been attached significant importance to their clinical treatment.
  Many researches prove that liver diseases are relative with free radical injury. The clinical application of treating liver diseases with free radical eradicators has a good effect.
  It was reported by Albuyu in 1978 that the peroxidation of free radicals plays an important role in liver injury mechanism and liver diseases such as virus hepatitis,medicine hepatitis,cirrhosis,etc .Experiments through animals prove that poisonous substances can cause the increase of the content of free radicals in the body so that liver cells face heavy necrosis , while the content of serum glutamic pyruvic transaminase increases . Consequently liver diseases have a bearing on the liver cell injury caused by free radicals in the liver or free radical peroixide.Liver , the biggest secretion organ in the body , participates in food digest.Furthermore, it’s also an important detoxication organ . Many detriment matters , including medicines , chemicals , are all transferred to harmless matters in the liver . During the process of transferring , great amount of free radicals are produced . When the amount is beyond that of the eradicating capacity of the liver , liver diseases occur.Free radicals cause the unsaturated multi-valence fatty acid in the liver cells to peroixidize fatty acid, destroying the structure of the cell membrane and its inner membrane, thus injuring the liver.Besides, free radicals are highly susceptible to be combined with membrane albumen and enzyme albumen so that decrease the content of anti-oxidizing matters and albumen in the cells, help to lower the quality of enzyme and the function of membrane in the cell containers, affect metabolizing material in the liver. Poisonous matters are directly transferred in liver highly reactive and active free radicals which are susceptible to be combined with unsaturated membrane fatty acid to destroy the cell structure, leading to the necrosis of liver cells , the decrease of liver function , the occurrence of some enzymes of liver cells in serum.
  Seeing from previous studies, we find that free radical is a significant factor to liver diseases. On this account, eliminating or fighting against free radicals is greatly meaningful to prevent the denaturation of liver cells and the occurrence of liver diseases. Owing to its low molecular weight and being easy to be absorbed, and its 20 –SH radicals with the nature of reduction in its molecules, MT can effectively eliminate the excessive free radicals in the body to prevent liver diseases.

MT & Nephropathy
  Nephropathy is a common and frequently-occurring disease, including acute or chronic glomerulus nephritis, interstitial nephritis, nephropyelitis, renal artery cirrhosis, renal insufficiency, etc. Kidney is an important organ which maintains the stability of inside environment, and it is the main drainage channel for body metabolite, extra moisture content and some toxic substances.Besides, it can absorb some substances which are useful to the body. Therefore, disease and dysfunction of kidney bear great harm to the body, and research on these diseases are attached great importance in both home and abroad.With the development of experimental techniques and instruments, research in nosogenesis of nephropathy has reached a new level, which is of profound meaning to the treatment of nephropathy.
  There are several inducing factors to nephropathy, such as infection and immunity maladjustment, which result in the structural breakage of nephridial tubule and glomerulus. According to the research, free radicals play an important role in the outbreak and development of nephropathy.Factors as kidney infection, immunity damage, toxicant damage and ischemia will lead to kidney leucocyte soakage and ischemia, hence giving birth to a great deal of free radicals.In normal conditions, kidney has the ability to scavenge free radicals. For example, MT and catalase in kidney are both scavenging agents of free radicals, keeping the production and elimination of free radicals in dynamic balance.However, when free radical productive ability surpasses the scavenging ability, or when aging results in the decline of free radical eliminating ability, free radicals will accumulate in the body.Extra free radicals will lead to damage of cells and organism. Free radicals may destroy the structure of glomerulus and nephridial tubule, or inophragma structure, or damage endodermis cells in blood vessel, hence damaging cells’ functional structure, declining releasing, absorbing and absorbing functions of kidney, so that albumen and hematid will come into being in urine.  
  Obviously, to eliminate extra free radicals is an important way to prevent and cure nephropathy.It can be found from the experiments that there are plenty of MT in liver and kidney, but when kidney is infected, its immunity damaged, or suffered from ischemia, free radicals will lead to damage to kidney, and so influencing its functions and leading to diseases. Therefore, appropriate supplement of MT can help prevent and cure nephropathy.

MT & Smoking
  China is a major tobacco-producing country and also the number one tobacco-consuming nation, consuming more than one forth of gross tobacco of the whole world.When ignited, tobacco will give off smog containing various toxicants, such as the well-known nicotine, tar, carbon dioxide, amine, pyridine compounds, acid, aldehyde, copper and nitrosamine, etc.Smoking can result in various diseases. Smoking is the main factor leading to cardiovascular disease, chronic bronchitis, emphysema, lung cancer, respiratory infection and gastric ulcer.Among the annual 660000 new lung cancer cases, 95 percent of them are related to smoking.
  It is proved in the experiment that besides manifold toxicants, a suck of smog contains one million (10⁶) order of magnitude of free radicals. That’s the main reason why smoking can speed aging and lead to diseases, and it can also explain why the passive smoking people will be harmed.The smog itself contains free radicals, and the toxicants it contains will also indirectly stimulate the production of free radicals. The summed number of free radicals in one suck of smog will not be smaller than 10¹³. if one pack of cigarette is consumed, the free radicals ingulfed and produced will be more than 10¹⁵. If the body has no self-scavenging ability, the sequence that such a vast amount of free radicals bring about would be extremely serious.However, the body’s free radical scavenging ability is limited, and due to the influence of factors of environmental pollution, diseases of the body and aging, the free radical eliminating ability of organism is declined, hence resulting in and aggravating some diseases. Consequently, to keep sound mind and body in a smoking environment, the most important is to eliminate free radicals.According to the research by scientists both in home and abroad, MT plays an important role in vital movement: MT has a free radical eliminating ability, 10,000 times stronger than superoxide dismutase(SOD).Scientists predict that the discovery and extensive use of MT will bring inestimable value to the health of people. MT has already been the focus that all the countries are trying to exploit and apply.

MT & Microelements
  Among the microelements of body organism which density order of magnitude ranges from mg/kg to mcg/kg, there are 14 considered indispensable substances for human beings; they are Iron, iodine, copper, zinc, manganese, cobalt, molybdenum, selenium, chromium, nickel, tin, silicon, fluorine and vanadium.The contents of these elements are not high in human body, but they are playing a physiological role that can not be ignored. People lacking one of the microelements will contract a corresponding disease.For example, iron deficiency leads to anemia, iodine deficiency leads to endemic goiter, zinc deficiency to growth retardation, and selenium deficiency to Keshan disease, etc. Through almost 40-year efforts, scientists from the United States, Japan, Germany and China have discovered that MT bears extremely unique and important physiological functions, playing an important and extensive role in vital movements. MT participates in the storage and metabolism of microelements in human body, keeping microelements in balance, adjusting metabolism of them, so that the host organism cells can exert their normal and ordered physiological functions.
  For example, MT participates in the metabolism of microelements as zinc and copper in human body. It is found in experiments that in most of MT separated from human body, zinc is the main combined metal. Besides, MT can be limited-strength combined with zinc and copper from foods, promoting the absorption of these microelements. Forasmuch, if a child has contracted the disease of zinc deficiency, supplementing MT together with zinc will help the absorption of zinc, and hence improve the recovery.